منابع مشابه
Improving SH3 domain ligand selectivity using a non-natural scaffold.
BACKGROUND Src homology 3 (SH3) domains bind sequences bearing the consensus motif PxxP (where P is proline and x is any amino acid), wherein domain specificity is mediated largely by sequences flanking the PxxP core. This specificity is limited, however, as most SH3 domains show high ligand cross-reactivity. We have recently shown that diverse N-substituted residues (peptoids) can replace the ...
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MOTIVATION Recovering the gene structures is one of the important goals of genome assembly. In low-quality assemblies, and even some high-quality assemblies, certain gene regions are still incomplete; thus, novel scaffolding approaches are required to complete gene regions. RESULTS We developed an efficient and fast genome scaffolding method called PEP_scaffolder, using proteins to scaffold g...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2008
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd2577